SPIDERMAN

Peter Parker (Tobey Maguire), his best friend Harry Osborn (James Franco), and Peter’s secret crush Mary Jane Watson (Kirsten Dunst) visit a genetics laboratory at Columbia University with their high school class. While taking photos in the laboratory, Peter is bitten on the hand by a genetically engineered “super spider”. Feeling unwell, he passes out shortly after arriving home. Meanwhile, scientist and owner of Oscorp Norman Osborn (Willem Dafoe), Harry’s father, is attempting to preserve his company’s military contract, knowing that its loss will mean the end of his business. He experiments on himself with his company’s new, but unstable, performance-enhancing chemical vapor which increases his speed, strength, and stamina. However, it also causes him to become insane and he kills his assistant, Mendel Stromm (Ron Perkins). The next morning, Peter wakes to find that his previously impaired vision has improved and that his body has metamorphosized into a more muscular physique. At school, he finds himself producing webbing and having the quick reflexes to avoid being injured in a fight with bully Flash Thompson (Joe Manganiello). Peter escapes from the school and realizes that he has acquired spider-like abilities from the spider bite. He quickly learns to scale walls, long jump across building rooftops and swing via webs from his wrists.
Lying to his aunt and uncle about where he is going, Peter decides to enter a wrestling tournament to get money to buy a car and impress Mary Jane. During an argument, Uncle Ben advises Peter, “With great power comes great responsibility.” Peter lashes out at his uncle and leaves for the tournament. Peter wins, but is cheated out of the contest money. In retaliation he allows a thief to escape with the promoter’s gate money. Afterward, Peter finds his uncle has been carjacked and killed. Peter tracks down the carjacker only to find out it was the same thief he allowed to escape earlier. After Peter disarms him, the carjacker tries to get away but falls out of a window and is killed. The same night, Norman kills a bunch of people, including General Slocum, who is threating to drive Norman out of business.